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Document Type

Original Article

Subject Areas

Botany and Microbiology

Keywords

Antibiotic sensitivity; Bacterial Coinfections; COVID-19; ICU

Abstract

The fact that patients with a viral respiratory infection are more likely to develop a bacterial infection and the recently reported prevalence of bacterial co-infection among COVID-19 patients in the ICU and its association with serious disease complications. However, the role of co-bacterial infection still needs a lot of study and research. This study was designed to investigate the frequency and etiology of bacterial infections in patients with COVID-19 admitted to the ICU and exploring their antibiogram sensitivity. We conducted the blind mini-bronchoalveolar lavage (BAL) sampling technique, VITEK 2 compact system for bacterial identification; K. pneumoniae was the most frequently reported pathogen, followed by P. Mirabilis and A. baumannii respectively. Antibiotic susceptibility testing was performed by two methods; according to CLSI guidelines using disc diffusion assay with 19 antibiotics and by VITEK 2-AST. The results proved the extensive multidrug resistant of co-bacterial pathogens to tested beta-lactams, carbapenems, aminoglycosides, quinolones, tetracycline, rifamycin and sulfonamide, however, P. Mirabilis showed considerable susceptibility to amikacin, while colistin was highly active against A. baumannii, in addition to sensitivity of K. pneumoniae for azteronam and colistin. This study may be useful in controlling nosocomial infections and the spread of antibiotic resistance and strict supervision of antibiotic stewardship programs.

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