Corresponding Author

Orabi, Hanaa

Document Type

Original Article

Subject Areas

Botany, Microbiology and Zoology


L-asparaginase; enzyme production; submerged fermentation and solid state fermentation


L-asparaginase produced by Bacillushalotolerans OHEM18 finds broad applications due to its hydrolysis activity so used as therapeutic agents in combination with additional medications in the cure of acute lymphoblastic leukemia and also in food processing. In the present study, L-asparaginase production was optimizedand the optimum factors for production under submerged fermentation (SMF) of the asparaginase were pH 7.0 after 28h using glucose and asparagine as carbon and nitrogen sources, respectively while bagasse was the best inducer for L-asparaginase production under SSF.

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