Document Type
Original Article
Subject Areas
Chemistry
Keywords
4-Thiazolidinones, thiazolo [3, 2-a] pyridines; and anthracene
Abstract
2-(4-Oxothiazolidin-2-ylidene)acetonitrile and ethyl -2-(4-oxothiazolidin-2-ylidene)acetate (1a,b),were condensedwith anthralaldehyde(1:1 molar ratio) and gave 4,5-dihydro- 4-oxothiazole derivatives (2a,b).Refluxingof 2-(antharacene-9-yl-methylene) malononitrile in acetic acid with thioglycollic acid gave(3).4-Thiaz -olidinones containing bis- aryl methylidine moieties(4a-c) and (5a,b)were produced via condensation of either(2a) or (3) with aromatic aldehydes(1:1 molar ratio). Heating of (2a) with α-substituted cinnamonitriles gave the expected substituted thiazolo[3,2-a] pyridines (6a-d),(7) and (9a-c). Thiazolo [3,2-a] pyridine enamino- nitrile (6a) was refluxed with formic acid and phenyl hydrazine to form the corres-ponding thiazolo [3,2-a] pyridine derivatives (10) and (11) derivatives respectively.The structures of the prepared compounds were confirmed by using spectroscopic techniques; IR; 1HNMR ;13C NMR and Mass spectroscopy. Also, Anibactreial and antifungal activity were evaluated for some of synthesized compounds.
How to Cite This Article
Khalil, Ali; Elisway, Raafat; Eyada, H.; Mohamed, Hazem; and El-Hag Ali, Gameel
(2014)
"SYNTHESIS, CHARACTERIZATION AND ANTIMICROBIAL EVALUATION OF SOME THIAZOLIDINONEDERIVATIVES BEARING PYRIDINE MOIETY: SEARCH FOR ANTIMIROBIAL AGENT,"
Al-Azhar Bulletin of Science: Vol. 25:
Iss.
2, Article 17.
DOI: https://doi.org/10.21608/absb.2014.23797