EFFECT OF LIPOPOLYSACCHARIDE AND THE AMELIORATIVE EFFECT OF THE ANTIOXIDANT MELATONIN ON SOME PHYSIOLOGICAL PARAMETERS OF SHEEP EMBRYOS

Authors

DIAA AHMED, Zoology Department, Faculty of Science, Al -Azhar University, Cairo, Egypt.
SAMIR ZAAHKOUK, Zoology Department, Faculty of Science, Al -Azhar University, Cairo, Egypt.
EL-YAMANI EL-ZWAHRY, Zoology Department, Faculty of Science, Al -Azhar University, Cairo, Egypt.

Corresponding Author

AHMED, DIAA

Document Type

Original Article

Subject Areas

Botany, Microbiology and Zoology

Keywords

LPS; Ameliorative; Melatonin; kidney; Liver; Blood

Abstract

As known, lipopolysaccharide (LPS) is a toxin that is secreted from gram negative bacteria as E. coli which is present in the gut of animals like sheep and it may be transported to the embryo through the blood affect the brain and other organs. Little is known about the effect of LPS on liver and kidney function or hematological parameters. In the present study we found that melatonin treatment improved most of the liver functions that affected by LPS injection and also improve kidney function, although LPS injection was found to lead to a decrease of createnine, urea and uric acid for unknown reason. concurrently injection of melatonin plus LPS led to decreasing most of blood indices while increasing of RBCs count and WBCs count. So, we concluded that usage of melatonin as general antioxidant is useful against LPS toxicity.

How to Cite This Article

AHMED, DIAA; ZAAHKOUK, SAMIR; and EL-ZWAHRY, EL-YAMANI (2012) "EFFECT OF LIPOPOLYSACCHARIDE AND THE AMELIORATIVE EFFECT OF THE ANTIOXIDANT MELATONIN ON SOME PHYSIOLOGICAL PARAMETERS OF SHEEP EMBRYOS," Al-Azhar Bulletin of Science: Vol. 23: Iss. 2, Article 2.
DOI: https://doi.org/10.21608/absb.2012.7210