UTILITY OF SOME SULPHA DRUGS IN SYNTHESIS OF NEW BIOLOGICALLY ACTIVE HETEROCYCLIC COMPOUNDS : SYNTHESIS AND ANTICANCER ACTIVITY OF SOME NOVEL THIOSEMICARBAZIDE DERIVATIVES

Authors

E. AHMED, Department of Chemistry, Faculty of Science (Girls), Al-Azhar University, Cairo, Egypt.
N. TAHA, Department of Chemistry, Faculty of Science (Girls), Al-Azhar University, Cairo, Egypt.
N. NADY, Department of Chemistry, Faculty of Science (Girls), Al-Azhar University, Cairo, Egypt.

Corresponding Author

AHMED, E.

Document Type

Original Article

Subject Areas

Chemistry

Keywords

SULPHA DRUGS; THIOSEMICARBAZIDE DERIVATIVES

Abstract

N-(4-(N-(2,6-dimethoxypyrimidin-4-yl)sulfamoyl)phenyl) hydrazine carbothioamide novel thiosemicarbazide (3) was used as starting material for synthesis of some novel Diacetyl hydrazine-carbothioamide (4), 1,3,4-Thiadiazol (7), 1,2-bis(carbothioamide) (9), 3,5-di-oxopyrazolidine (10), oxo-4,5-dihydropyrazole (11), 3,4-dihy-drophthalazine (15) and 3,6-dioxopiperazine (16).Where we found that, 1,2-bis(carbothioamide) (5), 1,2,4-triazole (6), carbamothioyl formohydrazonate (8) have anticancer activity of drug (s) using (E.A.C).

How to Cite This Article

AHMED, E.; TAHA, N.; and NADY, N. (2011) "UTILITY OF SOME SULPHA DRUGS IN SYNTHESIS OF NEW BIOLOGICALLY ACTIVE HETEROCYCLIC COMPOUNDS : SYNTHESIS AND ANTICANCER ACTIVITY OF SOME NOVEL THIOSEMICARBAZIDE DERIVATIVES," Al-Azhar Bulletin of Science: Vol. 22: Iss. 1, Article 8.
DOI: https://doi.org/10.21608/absb.2011.7175