SYNTHESIS OF SOME NOVEL THIAZOLE, AMINOTHIOPHENE, PYRIDINE, CHROMENE AND CHROMENOPYRIDINE DERIVATIVES

Authors

MOHAMED HELAL, Chemistry Department, Faculty of Science, Al-Azhar University, Cairo, Egypt

Corresponding Author

HELAL, MOHAMED

Document Type

Original Article

Subject Areas

Chemistry

Keywords

THIOPHENE; thiazole; thiazolidinone; 2-pyridones; Chromenes; chromenopyridines

Abstract

The behavior of intermediate 7 towards some α-halogenated compounds has been investigated to synthesize some novel thiophene and thiazole derivatives 9, 11, 12,14, and 15. Upon reacting 2-cyano-N'-(3, 4-dihydronaphthalen-1(2H)-ylidene) acetohydrazide (6) with acetylacetone, arylidenemalononitriles and/or CH3CHO/CH2(CN)2 afforded 2-pyridone derivatives 16,17 and 21. Treatment of compound 6 with DMF-DMA afforded N,N-dimethylaminomethylene derivative 22 which reacts with hydrazine hydrate to give α-tetraloneazine (23). Cyclocondensation of 6 with o-hydroxyacetophenone, dibromosalicyaldehyde and/or 2-hydroxyna-phthaldehyde produced chromene derivatives 26, 28a,b and 29.Treatment of 28a with CH2(CN)2 gave chromeno[3,4-c]-pyridine derivative 31.

How to Cite This Article

HELAL, MOHAMED (2011) "SYNTHESIS OF SOME NOVEL THIAZOLE, AMINOTHIOPHENE, PYRIDINE, CHROMENE AND CHROMENOPYRIDINE DERIVATIVES," Al-Azhar Bulletin of Science: Vol. 22: Iss. 1, Article 4.
DOI: https://doi.org/10.21608/absb.2011.7170