UTILITIES OF CYANOTHIOFORMAMIDES AND IMIDAZOLIDINEIMINO-THIONES IN THE SYNTHESIS OF NEW TYPES OF OXADIAZOLE, TRIAZOLTHIONE, BENZOTHIAZOLOQUINAZOLINONE, PYRROLO[2,3-B] PYRROLE AND IMIDAZOTRIAZINE DERIVATIVES OF BIOLOGICAL INTEREST.

Authors

F. MAHMOUD, Chemistry Department, Faculty of Science, Al-Azhar University (for Girls), Cairo, Egypt
N. TAHA, Chemistry Department, Faculty of Science, Al-Azhar University (for Girls), Cairo, Egypt
A. EL-SHARIEF, Chemistry Department, Faculty of Science, Al-Azhar University (for Boys), Cairo, Egypt
E. AHMED, Chemistry Department, Faculty of Science, Al-Azhar University (for Girls), Cairo, Egypt

Corresponding Author

MAHMOUD, F.

Document Type

Original Article

Subject Areas

Chemistry

Keywords

CYANOTHIOFORMAMIDES; IMIDAZOLIDINEIMINO-THIONES; Oxadiazole; TRIAZOLTHIONE

Abstract

Cyanothioformamides were reacted with benzoyl hydrazine, acetyl hydrazine and anthranilic acid to afford oxadiazole (4), triazolthione (5) and benzothiazoloquinazolinone derivatives (6) respectively. They also reacted with thiocarbohydrazide, semicarbazide, thiosemicarbazide and active methylene compounds to produce 3-hydrazino-1,2-,4-triazol-5-thione (8), thiocarbamoylsemicarbazide (9), triazolidinedithione (10). Treatment of imidazolidine iminothiones with different nucleophilic reagents gave imidazotriazines besides other imidazolidine derivatives. Some of the newly synthestized derivatives were screened for antibacterial and antifungal activity and showed prononced antimicrobial activity.

How to Cite This Article

MAHMOUD, F.; TAHA, N.; EL-SHARIEF, A.; and AHMED, E. (2011) "UTILITIES OF CYANOTHIOFORMAMIDES AND IMIDAZOLIDINEIMINO-THIONES IN THE SYNTHESIS OF NEW TYPES OF OXADIAZOLE, TRIAZOLTHIONE, BENZOTHIAZOLOQUINAZOLINONE, PYRROLO[2,3-B] PYRROLE AND IMIDAZOTRIAZINE DERIVATIVES OF BIOLOGICAL INTEREST.," Al-Azhar Bulletin of Science: Vol. 22: Iss. 1, Article 19.
DOI: https://doi.org/10.21608/absb.2011.7187