Part 2: SYNTHESIS AND REACTIONS OF SOME NEW IMIDAZO[4,5-C]PYRAZOLE AND PYRAZOLO[3,4-D]PYRIMIDINE DERIVATIVES

Authors

MONA KADAH, Chemistry Department, Faculty of Science (GIRLS), Al -Azhar University, Cairo, Egypt.
NAHED ABD EL-GHAFFAR, Chemistry Department, Faculty of Science (GIRLS), Al -Azhar University, Cairo, Egypt.
AZZA RADWAN, Chemistry Department, Faculty of Science (GIRLS), Al -Azhar University, Cairo, Egypt.
SARA ABD EL-AL, Chemistry Department, Faculty of Science (GIRLS), Al -Azhar University, Cairo, Egypt.
ASMAA SALMAN, Chemistry Department, Faculty of Science (GIRLS), Al -Azhar University, Cairo, Egypt.

Corresponding Author

ABD EL-GHAFFAR, NAHED

Document Type

Original Article

Subject Areas

Chemistry

Keywords

Pyrazoloimidazole; pyrazolopyrimidine; pyrazolone

Abstract

Reactions of 3-methyl-1-phenyl-4,6-dihydroimidazo[4,5-c]pyrazole-5(1H)-thione with carbonyl compounds gave the arylidene derivatives 2 and 3, with recinoleic acid, phosphorus oxychloride/phosphorus pentachloride mixture and copper bronze gave the adduct 4, the chloro derivative 5 and the dimer with desulfurization 7. The behaviour of the chloroderivative towards hydrazine and primary amines have also been studied. On the other, reaction of 5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one with aromatic aldehydes gave the arylidene derivatives 8a-d, which on reaction with thiourea gave the pyrazolopyrimidinethione derivatives 9. The behaviour of compounds 9 towards copper bronze, sodium nitrite/acetic acid mixture, acrylonitrile and formaldehyde/ morpholine and its reaction with compound 1 in presence of copper bronze have also been taken into consideration.

How to Cite This Article

KADAH, MONA; ABD EL-GHAFFAR, NAHED; RADWAN, AZZA; ABD EL-AL, SARA; and SALMAN, ASMAA (2009) "Part 2: SYNTHESIS AND REACTIONS OF SOME NEW IMIDAZO[4,5-C]PYRAZOLE AND PYRAZOLO[3,4-D]PYRIMIDINE DERIVATIVES," Al-Azhar Bulletin of Science: Vol. 20: Iss. 1, Article 9.
DOI: https://doi.org/10.21608/absb.2009.7547