4-pyrazine-2-carboxamido carboxylic acid derivatives; N-[4-(5-oxo-oxazol-2-yl)phenyl]pyrazine-2-carboxamides; N-[4-(1H-imidazol-2-yl)phenyl]pyrazine-2-carbox-amides; 1, 2, 4-triazine-6-one derivatives; Leuconostoc sp. Growth inhibitor
Synthesis and reactions of 4-pyrazine-2-carboxamido carboxylic acid derivatives 3a-c were studied. Various N-[4-(5-oxo-oxazol-2-yl)-phenyl]pyrazine-2-carboxamides 7-11 were obtained via condensation of 3c with different chemical reagents. Interaction of 10b,c with p-toludine and/or hydrazine hydrate afforded the corresponding N-[4-(1H-imidazol-2-yl)phenyl]pyrazine-2-carboxamides 12a,b respectively. Antimicrobial screening showed that 3c possess a promising effect against the growth of Leuconostoc sp. and other tested Gram-positive, Gram-negative and fungi. Thestructures of the newly derivatives were confirmed by IR, 1H NMR, 13C NMR and mass spectra studies.
How to Cite This Article
ABDELWAHAB, ASHRAF; EL-HADDAD, A.; EID, F.; BEDAIR, A.; ADAWY EL-DEEB, A.; and EL-SHERBENY, G.
"SYNTHESIS OF PYRAZINAMIDE DERIVATIVES AS LEUCONOSTOC MESENTEROIDES GROWTH INHIBITOR AND OTHER MICROORGANISMS,"
Al-Azhar Bulletin of Science: Vol. 18:
2, Article 15.