SYNTHESIS OF PYRAZINAMIDE DERIVATIVES AS LEUCONOSTOC MESENTEROIDES GROWTH INHIBITOR AND OTHER MICROORGANISMS

Authors

ASHRAF ABDELWAHAB, Department of Chemistry, Faculty of Science, Al-Azhar University, Nasr City 11884 Cairo, Egypt.
A. EL-HADDAD, Department of Chemistry, Faculty of Science, Al-Azhar University, Nasr City 11884 Cairo, Egypt.
F. EID, Department of Chemistry, Faculty of Science, Al-Azhar University, Nasr City 11884 Cairo, Egypt.
A. BEDAIR, Department of Chemistry, Faculty of Science, Al-Azhar University, Nasr City 11884 Cairo, Egypt.
A. ADAWY EL-DEEB, Department of Research abd Development Affair Sugar & Integrated Industries Companies, EL-Hwamdia, Giza
G. EL-SHERBENY, Department of Botany and Microbiology, Faculty of Science, Al-Azhar University, Nasr City 11884 Cairo, Egypt.

Corresponding Author

ABDELWAHAB, ASHRAF

Document Type

Original Article

Subject Areas

Chemistry

Keywords

4-pyrazine-2-carboxamido carboxylic acid derivatives; N-[4-(5-oxo-oxazol-2-yl)phenyl]pyrazine-2-carboxamides; N-[4-(1H-imidazol-2-yl)phenyl]pyrazine-2-carbox-amides; 1, 2, 4-triazine-6-one derivatives; Leuconostoc sp. Growth inhibitor

Abstract

Synthesis and reactions of 4-pyrazine-2-carboxamido carboxylic acid derivatives 3a-c were studied. Various N-[4-(5-oxo-oxazol-2-yl)-phenyl]pyrazine-2-carboxamides 7-11 were obtained via condensation of 3c with different chemical reagents. Interaction of 10b,c with p-toludine and/or hydrazine hydrate afforded the corresponding N-[4-(1H-imidazol-2-yl)phenyl]pyrazine-2-carboxamides 12a,b respectively. Antimicrobial screening showed that 3c possess a promising effect against the growth of Leuconostoc sp. and other tested Gram-positive, Gram-negative and fungi. Thestructures of the newly derivatives were confirmed by IR, 1H NMR, 13C NMR and mass spectra studies.

How to Cite This Article

ABDELWAHAB, ASHRAF; EL-HADDAD, A.; EID, F.; BEDAIR, A.; ADAWY EL-DEEB, A.; and EL-SHERBENY, G. (2007) "SYNTHESIS OF PYRAZINAMIDE DERIVATIVES AS LEUCONOSTOC MESENTEROIDES GROWTH INHIBITOR AND OTHER MICROORGANISMS," Al-Azhar Bulletin of Science: Vol. 18: Iss. 2, Article 15.
DOI: https://doi.org/10.21608/absb.2007.11124