NEW SYNTHESIS OF 1,4-DIARYLPIPERAZINE-2,5-DIONE AND 3,4,5-TRISUBSTITUTEDPYRIDINE-2(1H)-ONE

Authors

FATHI ABU-SHANAB, Chemistry Department, Faculty of Science, Al-Azhar University, Assiut 71524,

Corresponding Author

ABU-SHANAB, FATHI

Document Type

Original Article

Subject Areas

Chemistry

Keywords

1, 4-DIARYLPIPERAZINE-2, 5-DIONE; 3, 4, 5-TRISUBSTITUTEDPYRIDINE-2(1H)-ONE

Abstract

Treatment of N-aryl 2-chloroacetamides (2a-f) with sodium isopropoxide in isopropyl alcohol afforded 1,4-diarylppiperazine-2,5-dione (3a-f). Treatment of malononitrile dimer (9), ethyl cyanoacetate (11) and the arylidines of cyanothioacetamide (13) with DMFDMA afforded the corresponding enamines (10, 12 and 14) respectively. Reaction of 14 with either sodium ethoxide or sodium methoxide affords 5-cyano-4-ethoxy-6-oxo-1,6-dihydro-pyridine-3-carboxylic acid amide (15) and 5-cyano-4-methoxy-6-oxo-1,6-dihydro-pyridine-3-carboxylic acid amide (16) respectively.

How to Cite This Article

ABU-SHANAB, FATHI (2007) "NEW SYNTHESIS OF 1,4-DIARYLPIPERAZINE-2,5-DIONE AND 3,4,5-TRISUBSTITUTEDPYRIDINE-2(1H)-ONE," Al-Azhar Bulletin of Science: Vol. 18: Iss. 1, Article 3.
DOI: https://doi.org/10.21608/absb.2007.10871