SYNTHESIS AND BIOLOGICAL EFFECT OF SOME THIENO[2,3-D] PYRIMIDINE-4-(3H) ONE

Authors

NADIA SMEISS, Chemistry Department, Al-Azhar University (Girls), Faculty of Science, Cairo, Egypt.
NADIA SALEH, Chemistry Department, Al-Azhar University (Girls), Faculty of Science, Cairo, Egypt.
FIVIAN NOFEL, Pharmacology Department, National Research Center, Cairo, Egypt.
M. NASHWA, Chemistry Department, Al-Azhar University (Girls), Faculty of Science, Cairo, Egypt.

Corresponding Author

SMEISS, NADIA

Document Type

Original Article

Subject Areas

Botany, Microbiology and Zoology

Keywords

Biological effect; THIENO[2, 3-D] PYRIMIDINE-4-(3H) ONE

Abstract

Interaction of thiophene enamino ester 1a,b with the acid chloride of p-tolyl sulphonamido-N-acetic acid derivatives 2a-cafforded the corresponding amide derivatives respectively 3a-f. Hydrazinolysis of 3a-f with hydrazine hydrate yielded 4a-f. Diazotization of 1a then coupling with different amines gave 6a,b. compounds 7a,b was afforded when diazonium chloride of p-toludin or enamino thiophene 3-carboxylate (5) was reacted with compound 1a. Air oxidation of 6a yielded 8. Coupling was carried out with different amines compounds where 5 yielded 9a,b. According to Gewald method 11a-b was prepared from reaction of 10a,bwith malononitrile, From 11a,bwe can prepare compounds 13, 14a-c, 15a-c 16a,b, 17a,b, 18, 19 and 20. The structure of these compounds was confirmed by infrared, mass, H-NMR spectra the biological activity of some compounds were discussed and found to be active.

How to Cite This Article

SMEISS, NADIA; SALEH, NADIA; NOFEL, FIVIAN; and NASHWA, M. (2006) "SYNTHESIS AND BIOLOGICAL EFFECT OF SOME THIENO[2,3-D] PYRIMIDINE-4-(3H) ONE," Al-Azhar Bulletin of Science: Vol. 17: Iss. 1, Article 5.
DOI: https://doi.org/10.21608/absb.2006.11638