SYNTHESIS OF SOME NEW SUBSTITUTED MERCAPTOMETHYL PYRIMIDINES OF POSSIBLE BIOLOGICAL ACTIVITY

Authors

NAHED ABD EL-GHAFFAR, Chemistry Department , Faculty of Science , Al-Azhar University, Nasr City, Cairo.
NADIA DAWOOD, Chemistry Department , Faculty of Science , Al-Azhar University, Nasr City, Cairo.
BAHYIA EL.SADEK, Chemistry Department , Faculty of Science , Al-Azhar University, Nasr City, Cairo.

Corresponding Author

ABD EL-GHAFFAR, NAHED

Document Type

Original Article

Subject Areas

Botany, Microbiology and Zoology

Keywords

MERCAPTOMETHYL PYRIMIDINES

Abstract

4,6-Diaryl-2-mercaptomethyl pyrimidine derivatives (IIa,b) and (IIIa,b) were prepared. The reaction of IIa with phenylisothiocyanate afforded the corresponding N-phenylthiocarbamoyl derivative (IV) which was used as an intermediate for the synthesis of 1,3,4-thiadiazole (V), 1,3,4-triazole-2-thione-(VII) and 1,3,4-oxadiazole (VI)-5-methyl merca-ptopyrimidines. 1,3,4-Triazol-2-thione-5-methylmercaptopyrimidine(VII) was subjected to Mannich reaction. The reaction of 2-amino 1,3,4-thioadiazole-5-methyl mercaptopyrimidine (Vb) with active methylene compounds was also studied structural assignment of the prepared compounds were based on elemental and spectral data. Some of the prepared compounds were screened in vitro for their antibacterial activity.

How to Cite This Article

ABD EL-GHAFFAR, NAHED; DAWOOD, NADIA; and EL.SADEK, BAHYIA (2006) "SYNTHESIS OF SOME NEW SUBSTITUTED MERCAPTOMETHYL PYRIMIDINES OF POSSIBLE BIOLOGICAL ACTIVITY," Al-Azhar Bulletin of Science: Vol. 17: Iss. 1, Article 18.
DOI: https://doi.org/10.21608/absb.2006.11648