UTILITY OF ENAMINONITRILE IN THE SYNTHESIS OF NOVEL HETEROCYCLES BEARING PYRAZOLE MOIETY AND THEIR ANTIMICROBIAL AND CYTOTOXIC ACTIVITY ASSESSMENT

Authors

Galal Sayed, Departments of Organic Chemistry Lab., Chemistry, Faculty of Science, Ain Shams University
Mohamed Azab, Departments of Organic Chemistry Lab., Chemistry, Faculty of Science, Ain Shams University
Kurls Anwer, Departments of Organic Chemistry Lab., Chemistry, Faculty of Science, Ain Shams University
Nabil Negm, Petrochemical, Egyptian Petroleum Research Institute

Corresponding Author

Sayed, Galal

Document Type

Original Article

Subject Areas

Chemistry

Keywords

pyrazolopyrimidine; pyrazolothiazinethiones; pyrazolotetrazolopyrimidines; pyrazolotetrazolodiazepine; Antimicrobial; Cytotoxic activity

Abstract

Enaminonitrile derivatives 1a,b were used as a versatile material for the synthesis of different heterocyclic compounds such as pyrazoloacetamide, pyrazolopyrimidinone, pyrazolobenzamide, pyrazolopyrimidines, pyrazolothiazinethiones, pyrazolopyrimidinedithiones, pyrazolocyanoacetamide, pyrazolopyrazoles, tetrazolopyrazoles, pyrazolotetrazolopyrimidines, and pyrazolotetrazolodiazepine derivatives, through the reaction with different electrophiles and nucleophiles. The newly synthesized compound were tested against gram positive and gram negative bacteria, fungi and two human tumor cell lines.

How to Cite This Article

Sayed, Galal; Azab, Mohamed; Anwer, Kurls; and Negm, Nabil (2016) "UTILITY OF ENAMINONITRILE IN THE SYNTHESIS OF NOVEL HETEROCYCLES BEARING PYRAZOLE MOIETY AND THEIR ANTIMICROBIAL AND CYTOTOXIC ACTIVITY ASSESSMENT," Al-Azhar Bulletin of Science: Vol. 27: Iss. 1, Article 4.
DOI: https://doi.org/10.21608/absb.2016.24327